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Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

1 Jan 2020

Abstract excerpt

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson's disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen...

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PMID: 31940482
DOI: 10.1016/j.celrep.2019.12.078

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