Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration

Abstract excerpt

Significance We investigate microbe–host interaction in the context of neurodegeneration by screening for Escherichia coli genes whose deletion alleviates Parkinson’s disease symptoms in the nematode Caenorhabditis elegans overexpressing human α-synuclein (α-syn, A53T). The screen yields 38 E. coli genes that promote neurodegeneration. Two of these genes, csgA and csgB , code for proteins that form curli, one...

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