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Integrative single-cell and pan-cancer analyses identify LINC01871 and TBX21 as candidate regulators of antitumor T-cell immunity in breast cancer

2026-08-28

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade benefits only a subset of patients with breast cancer, and the molecular determinants of an effective CD8⁺ T-cell response remain incompletely understood. We integrated single-cell transcriptomes from primary breast tumors, breast cancer brain metastases and normal tissues with bulk RNA-sequencing data from The Cancer Genome Atlas (TCGA). Genes co-expressed wi...

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Literature Corpus work
dc99fbf1-dbb2-563b-8801-028790eeb996
DOI
10.21203/rs.3.rs-10586247/v1
Open publication

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Integrative single-cell and pan-cancer analyses identify LINC01871 and TBX21 as candidate regulators of antitumor T-cell immunity in breast cancerDOI 10.21203/rs.3.rs-10586247/v1
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