Article

Integrative Transcriptomic Analysis Identifies a Novel 22-Gene Signature Driving Breast Cancer Progression via the Proteasome-Chemokine Axis

2026-03-08

Abstract excerpt

<title>Abstract</title> <p> Breast cancer heterogeneity often limits traditional clinicopathological predictions. Using transcriptomic data from the SCAN-B cohort (N = 1,185), we developed a 22-gene prognostic signature via LASSO Cox regression. This signature successfully stratified patients into distinct risk groups, with the high-risk group showing significantly decreased overall survival ( <italic>p</italic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49042546-bc47-5b8f-9ba5-c91271727ae8
DOI: 10.21203/rs.3.rs-8948376/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Transcriptomic Analysis Identifies a Novel 22-Gene Signature Driving Breast Cancer Progression via the Proteasome-Chemokine AxisDOI 10.21203/rs.3.rs-8948376/v1Read

Integrative Transcriptomic Analysis Identifies a Novel 22-Gene Signature Driving Breast Cancer Progression via the Proteasome-Chemokine AxisSemantic proximity Read

Construction of a breast cancer predictive nomogram based on diverse cell death methods and reveal tumor microenvironment characterizationSemantic proximity Read

Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progressionSemantic proximity Read

Development of an Immune-Related Prognostic Signature in Breast CancerSemantic proximity Read

Construction and Validation of Immune-Related LncRNA Signature to Predict the Prognosis and Therapeutic Efficacy of Breast CancerSemantic proximity Read

LASSO Based Analysis for Prediction of Prognostic Signature Genes Associated with Breast CancerSemantic proximity Read

A mitochondrial quality regulation gene signature for prognosis and tumor microenvironment characterization in breast cancer: an integrative analysis with experimental validationSemantic proximity Read

Establishment of A Risk-Predicting Twenty-Two-Gene Signature Based on the Prognosis-Related RNA Binding Proteins of Breast CancerSemantic proximity Read

Landscape of Immune Cell Infiltration and Inflammatory Response-related Gene Signature in Breast Cancer: an Experimental Validation StudySemantic proximity Read

Integrated transcriptome and single-cell sequencing reveals M2-like tumor-associated macrophages-related prognostic signatures in breast cancerSemantic proximity Read

Identification and comparison of two risk models based on characteristic gene sets of breast cancer for predictive prognosisSemantic proximity Read