Article

Integrative Transcriptomic Analysis Identifies a Novel 22-Gene Signature Driving Breast Cancer Progression via the Proteasome-Chemokine Axis

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> Breast cancer heterogeneity often limits traditional clinicopathological predictions. Using transcriptomic data from the SCAN-B cohort (N = 1,185), we developed a 22-gene prognostic signature via LASSO Cox regression. This signature successfully stratified patients into distinct risk groups, with the high-risk group showing significantly decreased overall survival ( <italic>p</italic...

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Literature Corpus work: 83a48e0f-ea0e-5b9c-b9c0-ac25521540e7
DOI: 10.21203/rs.3.rs-8921240/v1

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