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Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance

2018-09-21

Abstract excerpt

Identification of recurrent driver mutations in genes encoding tyrosine kinases has resulted in the development of molecularly targeted strategies designed to improve the outcomes for patients diagnosed with acute myeloid leukemia (AML). The receptor tyrosine kinase FLT3, is the most commonly mutated gene in AML, with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) or missense mutations in...

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Literature Corpus work
dc993c19-2f3a-558d-b544-42494505431e
DOI
10.20944/preprints201809.0435.v1
Open publication

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Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least ResistanceDOI 10.20944/preprints201809.0435.v1
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