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FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development

10 Dec 2019

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase that plays an important role in hematopoietic cell survival, proliferation and differentiation. The most clinically important point is that mutation of the FLT3 gene is the most frequent genetic alteration and a poor prognostic factor in acute myeloid leukemia (AML) patients. There are two major types of FLT3 mutations: internal tandem...

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PMID: 31821677
DOI: 10.1111/cas.14274

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