Article
Understanding mechanisms of resistance to FLT3 inhibitors in adult FLT3-mutated acute myeloid leukemia to guide treatment strategy.
Critical reviews in oncology/hematology - 1 Sept 2024
Ruglioni Martina, Crucitta Stefania, Luculli Giovanna Irene, Tancredi Gaspare, Del Giudice Maria Livia, Mechelli Sandra, Galimberti Sara, Danesi Romano, Del Re Marzia
Abstract excerpt
The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable prognosis in patients affected by acute myeloid leukemia (AML). In this setting, in recent years, new FLT3 inhibitors have dem...
Topics
- Humans
- fms-Like Tyrosine Kinase 3
- Leukemia, Myeloid, Acute
- Drug Resistance, Neoplasm
- Mutation
- Protein Kinase Inhibitors
- Molecular Targeted Therapy
- Adult