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Article

Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete

6 Jul 2021

Abstract excerpt

Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful. The lack of genetic engineering tools has severely limited understanding of the mechanisms behind T. pallidum success as a pathogen. A recently described method for in vitro cultivation of T. pallidum, however, has made it possible to...

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PMID: 34228757
DOI: 10.1371/journal.ppat.1009612

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