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Article

ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia.

American journal of hematology - 1 Jul 2015

Elliott Michelle A, Pardanani Animesh, Hanson Curtis A, Lasho Terra L, Finke Christy M, Belachew Alem A, Tefferi Ayalew

Abstract excerpt

Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients with CSF3R-mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 (38%) harbored an ASXL1 and/or SETBP1 mutation (two patients expressed both), respectively. Two patients developed blastic transformation, both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Chronic

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Source

Identifiers

PMID: 25850813
DOI: 10.1002/ajh.24031

Genes

ASXL1
SETBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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