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Article

Mutated SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms.

Blood - 11 Aug 2022

Carratt Sarah A, Kong Garth L, Curtiss Brittany M, Schonrock Zachary, Maloney Lauren, Maniaci Breanna N, Blaylock Hunter Z, Baris Adrian, Druker Brian J, Braun Theodore P, Maxson Julia E

Abstract excerpt

Colony stimulating factor 3 receptor (CSF3R) mutations lead to JAK pathway activation and are the molecular hallmark of chronic neutrophilic leukemia (CNL). Approximately half of patients with CNL also have mutations in SET binding protein 1 (SETBP1). In this study, we developed models of SETBP1-mutated leukemia to understand the role that SETBP1 plays in CNL. SETBP1 mutations promote self-renewal of...

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Identifiers

PMID: 35482940
DOI: 10.1182/blood.2021014777
PMCID: PMC9373012

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Mutated SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms.PMID 35482940Read ↗

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