Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring

Abstract excerpt

<h4>Background and Aims</h4> Intergenerational disease transmission, where parental exposures or experiences influence disease susceptibility in offspring, may represent a crucial layer of stroke risk that extends beyond genetics alone. Environmental conditioning, such as intermittent sub-lethal hypoxia, can induce adaptive protective stress responses in the brain. However, whether such parental conditioning enha...

Topics

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• Behavior, Animal
• Disease Models, Animal
• Gene Expression
• Memory
• Mice
• Neuronal Plasticity
• Phenotype
• Stress Disorders, Post-Traumatic

Identifiers and source

Literature Corpus work

dc48cd0f-a907-5f7c-ae1f-c24f2166c9f7

DOI

10.1101/2025.07.02.662697