Article

Early-life stress facilitates the development of Alzheimer’s disease pathology via angiopathy

2020-04-29

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is a serious social problem. Recently, several early-life factors have been associated with an increased risk of a clinical diagnosis of AD. <h4>Methods</h4> We investigated the involvement of early-life stress in AD pathogenesis using heterozygous the amyloid precursor protein (APP) mutant mice ( App NL-G-F/wt ) and wild-t...

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Literature Corpus work: 67094191-48dd-5904-a3a2-de0c9de420ce
DOI: 10.1101/2020.04.27.062729

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