Article
Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channel.
The Journal of biological chemistry - 15 Aug 2003
Crawford Russell M, Jovanović Sofija, Budas Grant R, Davies Anthony M, Lad Harish, Wenger Roland H, Robertson Kevin A, Roy Douglas J, Ranki Harri J, Jovanović Aleksandar
Abstract excerpt
Chronic exposure to lower oxygen tension may increase cellular resistance to different types of acute metabolic stress. Here, we show that 24-h-long exposure to slightly decreased oxygen tension (partial pressure of oxygen (PO2) of 100 mm Hg instead of normal 144 mm Hg) confers resistance against acute hypoxia/reoxygenation-induced Ca2+ loading in heart-derived H9c2 cells. The number of ATP-sensitive K+ (K(ATP))...
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