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EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion

11 Jul 2023

Abstract excerpt

OBJECTIVES: Readily accessible human pancreatic beta cells that are functionally close to primary adult beta cells are a crucial model to better understand human beta cell physiology and develop new treatments for diabetes. We here report the characterization of EndoC-βH5 cells, the latest in the EndoC-βH cell family. METHODS: EndoC-βH5 cells were generated by integrative gene transfer of immortalizing transgenes...

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PMID: 37442376
DOI: 10.1016/j.molmet.2023.101772

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