Structural studies on histamine receptors

Abstract excerpt

The work presented in this thesis concerns a sub-family of the biologically important family of G-protein coupled receptors (GPCRs) known as histamine receptors. They are recognized as important drug targets for many disorders in mankind, such as allergic rhinitis and Alzheimer’s disease. This thesis has its roots in the first structure of histamine receptor H1, determined in complex with a first generation antihi...

Topics

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• Binding Sites
• Gene Expression
• GTP-Binding Proteins
• Mast cells and histamine
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Receptor Mechanisms and Signaling
• Sf9 Cells

Identifiers and source

Literature Corpus work

dc44a155-8764-5a00-abf9-ec79e9ec50e3

DOI

10.25560/56628