Article

The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway

2023-12-24

Abstract excerpt

<h4>ABSTRACT</h4> The Shoc2 scaffold protein is crucial in transmitting signals within the Epidermal Growth Factor Receptor (EGFR)-mediated Extracellular signal-regulated Kinase (ERK1/2) pathway. While the significance of Shoc2 in this pathway is well-established, the precise mechanisms through which Shoc2 governs signal transmission remain to be fully elucidated. Hereditary mutations in Shoc2 are responsible for...

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Literature Corpus work: 0848d87f-818d-5fda-a90f-8584201407cd
DOI: 10.1101/2023.12.23.573219

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