Article

Exploring vertical genomic heterogeneity and chemotherapy response using targeted genomic sequencing in muscle-invasive bladder cancer

2026-08-07

Abstract excerpt

We performed a targeted genomic sequence of muscle-invasive bladder cancer (MIBC) tissues to investigate vertical intratumoral heterogeneity, invasion processes, and potential biomarkers of platinum-based neoadjuvant chemotherapy (NAC) efficacy in MIBC. Mutations in key genes thought to be associated with MIBC were investigated using deep amplicon sequencing of tissue samples from 34 Japanese patients with MIBC, i...

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Literature Corpus work: dbf2e58d-52de-59b6-8f11-2777c1307446
DOI: 10.1186/s12894-026-02265-4

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