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Article

Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy.

EBioMedicine - 1 Sept 2018

Yang Zhao, Zhang Ruiyun, Ge Yunxia, Qin Xuying, Kang Xing, Wang Yue, Zhang Xu, Song Chengli, Quan Xiaofang, Wang Haifeng, Chen Haige, Li Chong

Abstract excerpt

The administration of neoadjuvant chemotherapy (NAC) preceding radical cystectomy benefits overall survival for patients with muscle-invasive bladder cancer (MIBC). However, the relationship between the genetic profiling of MIBC and NAC response remains unclear. Here, a mutation panel of six cancer-associated genes (TSC1, FGFR3, TERT, TP53, PIK3CA and ERBB2) and an immunohistochemistry (IHC) panel containing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 3

Source

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Identifiers

PMID: 29941343
DOI: 10.1016/j.ebiom.2018.06.011
PMCID: PMC6154770

Genes

FGFR3
ERCC1
ERBB2
BRCA1
EGFR
RRM1
TERT
TSC1
TUBB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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