Article

M2 Macrophage-Conditioned Medium Inhibits Intervertebral Disc Degeneration in a Tumor Necrosis Factor-α-rich Environment

2021-04-22

Abstract excerpt

<h4>Background: </h4> Inflammation is the primary pathological phenomenon associated with disc degeneration; accordingly, the inflammatory cytokine tumor necrosis factor (TNF-α) plays a crucial role in disc degeneration. M1 macrophages produce proinflammatory cytokines that facilitate the progression of intervertebral disc degeneration (IDD).However, the anti-inflammatory and regenerative effects of M2 macrophages...

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Literature Corpus work: dbb51501-050d-5765-a434-cd026a55218f
DOI: 10.21203/rs.3.rs-429415/v1

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