Article

Activation of LIMK/Cofilin signaling pathway via extracellular matrix-integrin interaction is critical for generation of mature and vascularized cardiac organoids

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease modeling. This study investigates the effects of cellular aggregate (CA) stemness and self-organization on the generation of mature and vascularized hPSC-COs and elucidates the mechanisms underlying CO maturation and...

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Literature Corpus work: 69363355-c5e5-5560-9972-acde1809f707
DOI: 10.21203/rs.3.rs-2798883/v1

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