Article

Self-assembly vascularized human cardiac organoids model cardiac diseases in petri dishes and in mice

2023-08-28

Abstract excerpt

In this study, we generated self-assembly cardiac organoids (COs) from human pluripotent stem cells by dual-phase modulation of Wnt/β-catenin pathway, utilizing CHIR99021 and IWR-1-endo. The resulting COs exhibited a diverse array of cardiac-specific cell lineages, cardiac cavity-like structures and demonstrated the capacity of spontaneous beating and vascularization in vitro . We further employed these complex a...

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Literature Corpus work: 67f03efc-8827-537e-8b7c-c39286071222
DOI: 10.1101/2023.08.26.554935

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