Article

C4 genetic structural variations affect multiple sclerosis risk and progression

2025-07-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Major histocompatibility complex (MHC) locus carries a significant genetic risk burden for multiple sclerosis (MS). Here we investigate the structurally diverse complement component 4 ( C4 ) alleles within the MHC in MS development and disease progression. <h4>Methods</h4> We imputed and examined C4 alleles based on data from two case-control cohorts (N 1 = 3252 cases and 57...

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Literature Corpus work: db6f0196-1531-5c95-bfc7-9027549e7f58
DOI: 10.1101/2025.07.28.25332292

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