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Article

Iron uptake mediated by TFRC and secretion of transferrin types stimulate thermogenic activation in human adipocytes

2025-11-26

Abstract excerpt

Adrenergic-driven thermogenic activation of brown adipose tissue requires high amounts of nutrients including iron supporting mitochondrial biogenesis. This was governed by rapid gene expression changes in human cervical-derived brown adipocytes. Transferrin receptor 1 (TFRC) was strongly upregulated in response to dibutyryl-cAMP. Pharmacological inhibition and siRNA-mediated knockdown of TFRC during adrenergic st...

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Identifiers and source

Literature Corpus work
db4079df-053e-5132-886f-3f86d056ec67
DOI
10.1101/2025.11.24.690185
Open publication

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Iron uptake mediated by TFRC and secretion of transferrin types stimulate thermogenic activation in human adipocytesDOI 10.1101/2025.11.24.690185
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