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Upregulation of inhibitor of DNA binding 1 and 3 is important for efficient thermogenic response in human adipocytes

16 Nov 2024

Abstract excerpt

Brown and beige adipocytes can be activated by β-adrenergic agonist via cAMP-dependent signaling. Performing RNA-sequencing analysis in human cervical area-derived adipocytes, we found that dibutyryl-cAMP, which can mimic in vivo stimulation of browning and thermogenesis, enhanced the expression of browning and batokine genes and upregulated several signaling pathway genes linked to thermogenesis. We observed...

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PMID: 39550428
DOI: 10.1038/s41598-024-79634-2

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