Article

Altered Short Non-Coding RNAs Landscape in the Hippocampus of a Mouse Model of CDKL5 Deficiency Disorder

2025-09-01

Abstract excerpt

CDKL5 deficiency disorder (CDD) is a rare developmental epileptic encephalopathy (DEE) caused by mutations in cyclin-dependent kinase-like 5 (CDKL5). The clinical manifestations include early and severe epilepsy, intellectual disability, motor abnormalities, and cortical visual impairments. The pathophysiological mechanisms underlying CDD are not fully understood and current treatments are limited to symptomatic m...

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Literature Corpus work: bc91ccb5-2da5-53f4-a634-69ec2f3d2bf0
DOI: 10.20944/preprints202509.0061.v1

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