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Article

Reconstitution of the Ste24p-dependent N-terminal proteolytic step in yeast a-factor biogenesis.

The Journal of biological chemistry - 3 Mar 2000

Schmidt W K, Tam A, Michaelis S

Abstract excerpt

The yeast mating pheromone a-factor precursor contains an N-terminal extension and a C-terminal CAAX motif within which multiple posttranslational processing events occur. A recently discovered component in a-factor processing is Ste24p/Afc1p, a multispanning endoplasmic reticulum membrane protein that contains an HEXXH metalloprotease motif. Our in vivo genetic characterization of this protein has demonstrated...

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Identifiers

PMID: 10692417
DOI: 10.1074/jbc.275.9.6227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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