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Article

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.

The Journal of biological chemistry - 1 Jan 2000

Babatz Timothy D, Spear Eric D, Xu Wenxin, Sun Olivia L, Nie Laiyin, Carpenter Elisabeth P, Michaelis Susan

Abstract excerpt

The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 that prevent cleavage cause the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS) and related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33293369
DOI: 10.1074/jbc.RA120.015792
PMCID: PMC7948416

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Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.PMID 33293369Read ↗

Cleavage Site Specificity for Processing of Farnesylated Prelamin A by the Zinc Metalloprotease ZMPSTE24Semantic proximity Read ↗

Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24Semantic proximity Read ↗

Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.Semantic proximity Read ↗

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability.Semantic proximity Read ↗

<i>ZMPSTE24</i> Missense Mutations that Cause Progeroid Diseases Decrease Prelamin A Cleavage Activity and/or Protein StabilitySemantic proximity Read ↗

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.Semantic proximity Read ↗

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.Semantic proximity Read ↗

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.Semantic proximity Read ↗

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice.Semantic proximity Read ↗

Ste24: An Integral Membrane Protein Zinc Metalloprotease with Provocative Structure and Emergent Biology.Semantic proximity Read ↗

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.Semantic proximity Read ↗

A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS.Semantic proximity Read ↗

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