Article
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.
The EMBO journal - 1 Jul 1991
Hrycyna C A, Sapperstein S K, Clarke S, Michaelis S
Abstract excerpt
Post-translational processing of a distinct group of proteins and polypeptides, including the a-factor mating pheromone and RAS proteins of Saccharomyces cerevisiae, results in the formation of a modified C-terminal cysteine that is S-isoprenylated and alpha-methyl esterified. We have shown previously that a membrane-associated enzymatic activity in yeast can mediate in vitro methylation of an isoprenylated...
Topics
- Amino Acid Sequence
- Cell Membrane
- Escherichia coli
- Fungal Proteins
- Genes, Fungal
- Kinetics
- Mating Factor
- Methylation
- Molecular Sequence Data
- Mutation
- Peptides