Article
A dynamic microRNA profile that tracks a chemotherapy resistance phenotype in osteosarcoma. Implications for novel therapeutics
2024-06-20
Abstract excerpt
<h4>ABSTRACT</h4> Osteosarcoma is a rare primary bone tumor for which no significant therapeutic advancement has been made since the late 1980s despite ongoing efforts. Overall, the five-year survival rate remains about 65%, and is much lower in patients with tumors unresponsive to methotrexate, doxorubicin, and cisplatin therapy. Genetic studies have not revealed actionable drug targets, but our group, and others...
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Identifiers and source
- Literature Corpus work
- db0eae71-6186-55ff-9ae8-44aa731ae6c7
- DOI
- 10.1101/2024.06.19.24309087