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Article

MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma.

Scientific reports - 10 Mar 2020

Lietz Christopher E, Garbutt Cassandra, Barry William T, Deshpande Vikram, Chen Yen-Lin, Lozano-Calderon Santiago A, Wang Yaoyu, Lawney Brian, Ebb David, Cote Gregory M, Duan Zhenfeng, Hornicek Francis J, Choy Edwin, Petur Nielsen G, Haibe-Kains Benjamin, Quackenbush John, Spentzos Dimitrios

Abstract excerpt

There is a lack of well validated prognostic biomarkers in osteosarcoma, a rare, recalcitrant disease for which treatment standards have not changed in over 20 years. We performed microRNA sequencing in 74 frozen osteosarcoma biopsy samples, constituting the largest single center translationally analyzed osteosarcoma cohort to date, and we separately analyzed a multi-omic dataset from a large NCI supported...

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Identifiers

PMID: 32157112
DOI: 10.1038/s41598-020-61236-3
PMCID: PMC7064533

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