Article

ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer

2020-09-08

Abstract excerpt

<title>Abstract</title> <p>Background To comprehensively understand the molecular mechanism of tamoxifen resistance (TamR) acquisition by epigenetically regulated genes, it is essential to identify pivotal genes by genome-wide methylation analysis and verify their function in xenograft animal model and cancer patients. Methods The MCF-7/TamR breast cancer cell line was developed and a genome-wide methylation ar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db09cf34-8777-530a-895f-89d3df49f8c8
DOI: 10.21203/rs.3.rs-69357/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancerDOI 10.21203/rs.3.rs-69357/v1Read

Characterizing novel molecular mechanisms involved in breast cancer tumourigenesis/progression and tamoxifen resistanceSemantic proximity Read

Recent Insights Into Breast Cancer: Molecular Pathways, Epigenetic Regulation, and Emerging Targeted TherapiesSemantic proximity Read

AKT-Induced Tamoxifen Resistance Is Overturned by RRM2 InhibitionSemantic proximity Read

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goalsSemantic proximity Read

The EO771 mammary cancer cell line displays a luminal B phenotype and it is sensitive to anti-estrogen treatmentsSemantic proximity Read

Overview of the therapeutic strategies for ER positive breast cancer.Semantic proximity Read

EZH2 mutation is associated with the development of visceral metastasis by enhancing proliferation and invasion and inhibiting apoptosis in breast cancer cells.Semantic proximity Read

Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2- Breast CancerSemantic proximity Read

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine ResistanceSemantic proximity Read

Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy ResistanceSemantic proximity Read

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progressionSemantic proximity Read

Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancerSemantic proximity Read