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Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

27 Jun 2023

Abstract excerpt

FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and cancer growth and progression. It is expressed in all subtypes of breast cancer and is the factor most associated with risk of poor patient survival, especially so in triple negative breast cancer (TNBC). Thus, new approaches to inhibiting FOXM1 and...

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PMID: 37370117
DOI: 10.1186/s13058-023-01675-8

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