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Article

Mechanism of CFTR correction by type I folding correctors.

Cell - 6 Jan 2022

Fiedorczuk Karol, Chen Jue

Abstract excerpt

Small molecule chaperones have been exploited as therapeutics for the hundreds of diseases caused by protein misfolding. The most successful examples are the CFTR correctors, which transformed cystic fibrosis therapy. These molecules revert folding defects of the ΔF508 mutant and are widely used to treat patients. To investigate the molecular mechanism of their action, we determined cryo-electron microscopy...

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Identifiers

PMID: 34995514
DOI: 10.1016/j.cell.2021.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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