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Article

Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.

Scientific reports - 16 Jun 2017

Pereira Jose H, McAndrew Ryan P, Sergeeva Oksana A, Ralston Corie Y, King Jonathan A, Adams Paul D

Abstract excerpt

The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropathies, making TRiC a potential therapeutic target. A detailed structural understanding of its ATP-dependent folding mechanism and substrate recognition is therefore of great...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28623285
DOI: 10.1038/s41598-017-03825-3
PMCID: PMC5473854

Genes

CCT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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