Article

“Centrosome Amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation”

2022-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Centrosome amplification (CA) is a prominent feature of human cancers linked to genomic instability and tumourigenesis in vivo . CA is observed as early as pre-malignant metaplasia, with CA incidence increasing as the disease progresses from dysplasia to neoplasia. However, the mechanistic contributions of CA to tumourigenesis (tumour architecture and remodelling) are poorly understood. Using...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dafac20c-2698-5345-98b7-a3b6be5c7db9
DOI: 10.1101/2022.05.09.490051

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

“Centrosome Amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation”DOI 10.1101/2022.05.09.490051Read

Aurora kinase A enables collective invasion and metastasis by endowing a leader cell phenotype and stabilizing Eplin-mediated cohesion with follower cellsSemantic proximity Read

Transcriptomic profile reveals molecular events associated to focal adhesion and invasion in canine mammary gland tumour cell linesSemantic proximity Read

Deciphering Stromal Changes between Metastatic and Non-metastatic Canine Mammary CarcinomasSemantic proximity Read

p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells.Semantic proximity Read

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesisSemantic proximity Read

A look into the link between centrosome amplification and breast cancerSemantic proximity Read

DLC1 loss drives multicellular streaming invasion by enforcing spatially coordinated Rho and β1 integrin signalingSemantic proximity Read

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplificationSemantic proximity Read

Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplificationSemantic proximity Read

Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.Semantic proximity Read

Cell polarity signaling in the plasticity of cancer cell invasivenessSemantic proximity Read

Rap1 Integrates Tissue Polarity, Lumen Formation, and Tumorigenic Potential in Human Breast Epithelial CellsSemantic proximity Read