Article

ADNC-RS, a clinical-genetic risk score, predicts Alzheimer’s pathology in autopsy-confirmed Parkinson’s Disease and Dementia with Lewy Bodies

2020-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Growing evidence suggests overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD) pathophysiology in a subset of patients. Indeed, 50-80% of autopsy cases with a primary clinicopathological diagnosis of Lewy body disease (LBD) – most commonly manifesting during life as PD – have concomitant amyloid-beta and tau pathology, the defining pathologies of AD. Here we evaluated common gene...

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Literature Corpus work: daa696fc-d0f4-54c3-91fa-c7b93b68ed4c
DOI: 10.1101/2020.04.07.20056614

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