Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies.

Acta neuropathologica - 1 Oct 2020

Dai David L, Tropea Thomas F, Robinson John L, Suh Eunran, Hurtig Howard, Weintraub Daniel, Van Deerlin Vivianna, Lee Edward B, Trojanowski John Q, Chen-Plotkin Alice S

Abstract excerpt

Growing evidence suggests overlap between Alzheimer's disease (AD) and Parkinson's disease (PD) pathophysiology in a subset of patients. Indeed, 50-80% of autopsy cases with a primary clinicopathological diagnosis of Lewy body disease (LBD)-most commonly manifesting during life as PD-have concomitant amyloid-beta and tau pathology, the defining pathologies of AD. Here we evaluated common genetic variants in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Lewy Body Disease

Share to Neurofibrillary Tangles

Share to Parkinson Disease

Share to Plaque, Amyloid

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32749525
DOI: 10.1007/s00401-020-02199-7
PMCID: PMC7864557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies.PMID 32749525Read ↗

ADNC-RS, a clinical-genetic risk score, predicts Alzheimer’s pathology in autopsy-confirmed Parkinson’s Disease and Dementia with Lewy BodiesSemantic proximity Read ↗

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysisSemantic proximity Read ↗

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.Semantic proximity Read ↗

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer’s disease and related dementias in a multi-site autopsy cohortSemantic proximity Read ↗

Investigation of the genetic aetiology of Lewy body diseases with and without dementiaSemantic proximity Read ↗

Assessment of genetic risk for improved clinical-neuropathological correlations.Semantic proximity Read ↗

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseasesSemantic proximity Read ↗

Genetic risk factor clustering within and across neurodegenerative diseasesSemantic proximity Read ↗

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathologySemantic proximity Read ↗

The Genetics of Dementia with Lewy Bodies: Current Understanding and Future DirectionsSemantic proximity Read ↗

<i>APOE</i>-<i>ε</i>4 and<i>BIN1</i>increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathologySemantic proximity Read ↗

Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer's-type dementia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.