Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

doi:10.1371/journal.pgen.1012170

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Article

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics - 1 Jun 2026

Cholerton Brenna, Godrich Dana, Pasteris Jeremy, Rivero Joe, Martin Eden R, Kunkle Brian W, Naj Adam C, Hamilton-Nelson Kara L, Wang Hui, Lee Wan-Ping, Dumitrescu Logan, Hohman Timothy J, Mayeux Richard, Larson Eric B, Crane Paul K, Keene C Dirk, Latimer Caitlin S, Mukherjee Shubhabrata, Kofler Julia K, Kamboh M Ilyas, Bennett David A, Molina-Porcel Laura, Cuccaro Michael, Pericak-Vance Margaret A, Rundek Tatjana, Scott William K, Kukull Walter, Schellenberg Gerard, Beecham Gary W, Montine Thomas J

Abstract excerpt

Understanding the genetic foundations of dementia is critical to unraveling its complex molecular basis. Given that a clinical diagnosis of Alzheimer's disease (AD) dementia often results from interplay between multiple underlying neuropathologic co-morbidities, previous genome-wide association studies (GWAS) of clinically diagnosed AD are restricted in their ability to translate genetic associations to potential...

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PMID: 42371968
DOI: 10.1371/journal.pgen.1012170
PMCID: PMC13340787

Genes

SNCA
APOE
BIN1
DOCK4
EED
EPHA5
GRN
PICALM
PSMG1
SLAIN2
SLC10A4
TMEM106B
VAPA

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