Back to search

Article

Foxp3 and CD68 as Potential Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Solid Tumor

2023-01-18

Abstract excerpt

Immune checkpoint inhibitors (ICI) are currently use in a wide range of tumors, but only 20-40% of patients achieve clinical benefit. Aim of our study was to find predictive biomarkers of ICI treatment. We analyzed by immunohistochemistry various cell subsets, including CD3+ cells, CD8+ cells, CD68+ cells, CD20+ cells, FoxP3+ cells, and molecules as LAG-3, IDO1, TGfβ. Comprehensive genomic profiles were analy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8069ab1-64a0-508e-8a32-fce36f751f9f
DOI
10.20944/preprints202301.0325.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Foxp3 and CD68 as Potential Predictors of Response to Immune Checkpoint Inhibitors in Patients with Advanced Solid TumorDOI 10.20944/preprints202301.0325.v1
Immune Checkpoints are Predominantly Co-Expressed by Clonally Expanded CD4+FoxP3+ Intratumoral T-cells in Primary Human CancersSemantic proximity
Counterbalance of Foxp3 and IDO expression at different tumor stages in aggressive breast cancer subtypesSemantic proximity
Comprehensive Pan-Cancer Analysis of 33 Human Cancers Reveals the Immunotherapy Value of FOXP3Semantic proximity
Biomarker for personalized immunotherapySemantic proximity
Common phenotypic dynamics of tumor-infiltrating lymphocytes across different histologies upon checkpoint inhibition: impact on clinical outcome.Semantic proximity
FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.Semantic proximity
Identification of an immune overdrive high-risk subpopulation with aberrant expression of FOXP3 and CTLA4 in colorectal cancer.Semantic proximity
Role of CD68 in Tumor Immunity and Prognosis Prediction: A Pan-Cancer AnalysisSemantic proximity
Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4Semantic proximity
The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy.Semantic proximity
A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancerSemantic proximity
CD4 <sup>+</sup> Foxp3E2 <sup>+</sup> regulatory T cell frequency predicts breast cancer prognosis and recurrenceSemantic proximity
Select a neighboring publication to make it the new centre.