Article

The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in <i>C. elegans</i>

2018-03-05

Abstract excerpt

UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C. elegans UBR-1 leads to a specific motor deficit: when adult animals generate reversal movements, A-class motor neurons exhibit synchronized activation, preventing body bending. Th...

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Literature Corpus work: da879704-9233-5025-b6e0-c81e7cf5a534
DOI: 10.1101/198994

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