Article

Integrated single-nuclei and spatial transcriptomic profiling of human sacrococcygeal teratomas reveals heterogeneity in cellular composition and X-chromosome inactivation

2025-07-24

Abstract excerpt

Sacrococcygeal teratomas (SCTs) are the most common neonatal tumors, yet their cellular origins, clinical stratification, and sex bias–occurring three times more in XX than XY individuals—remain poorly understood. To address these gaps, we examined six postnatal (one male and five female) and two prenatal (both female) SCTs by single nuclei RNA-seq and spatial transcriptomics. We identified five broad cellular lin...

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Literature Corpus work: da75be66-e083-58ff-9921-abc9678edf67
DOI: 10.1101/2025.07.21.665156

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Integrated single-nuclei and spatial transcriptomic profiling of human sacrococcygeal teratomas reveals heterogeneity in cellular composition and X-chromosome inactivationDOI 10.1101/2025.07.21.665156Read

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