Article

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

2022-08-05

Abstract excerpt

c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To achieve this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters and represses the expression of Thioredoxin Interacting Protein (TXNIP), which is a potent negative regulator of glucose uptake. A Myc high /TXNIP low gene signature is clinically significant as it correlates w...

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Literature Corpus work: da5cd54c-2a6e-5410-9c8f-24c8f0878f3e
DOI: 10.1101/2022.08.04.502753

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