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Article

TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

17 Mar 2023

Abstract excerpt

The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expression of thioredoxin interacting protein (TXNIP), which is a potent negative regulator of glucose uptake. A Mychigh/TXNIPlow gene signature is clinically significant...

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PMID: 36930677
DOI: 10.1371/journal.pbio.3001778

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