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Article

The mTOR Signaling Pathway in Pediatric Neuroblastoma

22 May 2013

Abstract excerpt

Neuroblastoma (NB) is the most common extracranial malignant solid tumors of childhood, and the majority of these high-risk tumors is resistant to nearly all the treatments and has a significantly worse outcome. The mammalian target of rapamycin (mTOR) plays a critical role in oncogenesis and cancer progression of many tumors. This review will describe the function of mTOR, its genetic regulation in pediatric...

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PMID: 23697980
DOI: 10.3109/08880018.2013.798058

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