Article

Replication-first reciprocal genome editing resolves ANKRD1 as a convergent regulatory target at the 17q21.31 locus

2026-02-13

Abstract excerpt

<title>Abstract</title> <p> <italic> <bold>Background</bold> </italic> <italic>:</italic> The 17q21.31 locus is structurally complex, harboring a common H1/H2 inversion and dense regulatory variation; one of the two SNPs studied lies within the inversion and the other outside it. Disentangling the effects of individual non-coding variants in this context remains challenging. We used reciprocal double-editing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da4eec9f-ae6a-58c4-a804-b985db54f90f
DOI: 10.21203/rs.3.rs-8728680/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Replication-first reciprocal genome editing resolves ANKRD1 as a convergent regulatory target at the 17q21.31 locusDOI 10.21203/rs.3.rs-8728680/v1Read

Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases.Semantic proximity Read

The complete diploid reference genome of RPE-1 identifies human phased epigenetic landscapesSemantic proximity Read

Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2BSemantic proximity Read

Determining the impact of uncharacterized inversions in the human genome by droplet digital PCRSemantic proximity Read

Haplotype-resolved inversion landscape reveals hotspots of mutational recurrence associated with genomic disordersSemantic proximity Read

A proteome-wide dependency map of protein interaction motifsSemantic proximity Read

A proteome-wide dependency map of protein interaction motifs.Semantic proximity Read

Haplotype synthesis analysis in public reference data reveals functional variants underlying known genome-wide associated susceptibility lociSemantic proximity Read

Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript.Semantic proximity Read

Adaptive long-read and transcriptome sequencing detail a submicroscopic inv(15)(q14q15), generating fusion transcripts and MEIS2 and NUSAP1 haploinsufficiencySemantic proximity Read

Genome writing and Targeted Delivery of the <i>NKX6-3/ANK1</i> gene cluster and its Type 2 Diabetes GWAS Variants to Human iPSCsSemantic proximity Read

Structural haplotypes and recent evolution of the human 17q21.31 region.Semantic proximity Read