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Article

Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript.

PLoS genetics - 1 Oct 2015

Puig Marta, Castellano David, Pantano Lorena, Giner-Delgado Carla, Izquierdo David, Gayà-Vidal Magdalena, Lucas-Lledó José Ignacio, Esko Tõnu, Terao Chikashi, Matsuda Fumihiko, Cáceres Mario

Abstract excerpt

Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. Here we present a global analysis of a new 415-kb polymorphic inversion that is among the longest ones...

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Identifiers

PMID: 26427027
DOI: 10.1371/journal.pgen.1005495
PMCID: PMC4591017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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