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Article

CRISPR/Cas9: A Powerful Strategy to Improve CAR-T Cell Persistence

1 Aug 2023

Abstract excerpt

As an emerging treatment strategy for malignant tumors, chimeric antigen receptor T (CAR-T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly improved in the past decade. However, the clinical effect of CAR-T therapy is not so satisfying, especially in solid tumors. Even in hematologic malignancies, a proportion of patients eventually relapse after receiving CAR-T cell...

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PMID: 37569693
DOI: 10.3390/ijms241512317

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