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CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma

26 Jun 2020

Abstract excerpt

Cancer cells commonly develop resistance to immunotherapy by loss of antigen expression. Combinatorial treatments that increase levels of the target antigen on the surface of cancer cells have the potential to restore efficacy to immunotherapy. Here, we use our CRISPR interference- and CRISPR activation-based functional genomics platform to systematically identify pathways controlling cell surface expression of...

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PMID: 32589729
DOI: 10.1182/bloodadvances.2019001346

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