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Generating multispecific antibodies through column-based redox reactions: Part I

2024-11-07

Abstract excerpt

Multispecific antibodies are increasingly being explored in the pharmaceutical industry for unmet patient needs. This work focuses on generating these molecules through an electrostatic-steering strategy, where two separate parent homodimer antibodies are expressed and purified, then combined into the heterodimer multispecific through reduction and oxidation chemistry. Traditional operations for electrostatic stee...

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Literature Corpus work
da436d1a-8b5f-50da-9967-b60862c66a78
DOI
10.22541/au.173099719.90268754/v1
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